ABOUT
HYPERTROPHIC CARDIOMYOPATHY (HCM)

Many people may be unfamiliar with HCM, but it’s actually the most commonly inherited heart disease. Learn who may be at risk, what happens to the heart, and the difference between 2 types of HCM.

Many people may be unfamiliar with HCM, but it’s actually the most commonly inherited heart disease. Learn who may be at risk, what happens to the heart, and the difference between 2 types of HCM.

Who is at risk of HCM

HCM can affect anyone regardless of age, gender, or ethnicity.

  • The reported prevalence of HCM ranges from 1 in 200 to 1 in 500 people in the general population*
  • However, only ~100,000 patients in the US have been diagnosed with HCM, which suggests that approximately 85% may remain undiagnosed‡§
  • HCM can be an inherited disease, meaning it can run in families. However, not all cases of HCM are genetic

~85%

of people with HCM are

UNDIAGNOSED

*The 1995 CARDIA study, a multicenter, US-population-based echocardiography study of 4111 subjects (aged 23-35) identified the prevalence of HCM as 1:500 people in the general population.

The 2015 Semsarian publication identified that the prevalence of HCM gene carriers could be as high as 1:200.

Based on 2013 ICD-9 claims data analysis (N=169,089,614): An estimated 700,000 overall US prevalence of HCM (1. ~100,000 patients with diagnosed HCM [based on 2013 US Census population], 2. ~600,000 patients with undiagnosed HCM [based on analysis’ assumption that 1 in 500 prevalence represents clinically unrecognized cases]).

§Estimated undiagnosed range calculated using prevalence of 1:500, estimated US population (332,330,571 in May 2021), and estimated diagnosed population (~100,000).

What happens to
the heart in HCM

The heart is a muscle that pumps oxygen-rich blood around the body by contracting and relaxing.

In someone with HCM, the walls of the heart become thicker than they should be. This excessive
thickening can cause the heart to become more stiff and leaves less room for blood to fill the heart.

healthy heart and heart with hypertrophic cardiomyopathy (HCM)
healthy heart and heart with hypertrophic cardiomyopathy (HCM)

This means a heart affected by HCM has to work harder and may have difficulty pumping oxygen-rich blood out to the rest of the body. As a result, those with HCM can experience a lack of energy, a fast heartbeat, chest pain, or other symptoms.

Watch the video to learn more about HCM and what happens in the body when a person has HCM.

click to learn more about hypertrophic cardiomyopathy (HCM)

TWO TYPES OF HCM:
LEARN THE DIFFERENCE

Two types of HCM are: non-obstructive HCM and obstructive HCM. Both types of HCM result in thicker heart
walls, but in obstructive HCM, the thicker wall may block or reduce blood flow out of the heart.

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